Effect of acute in vivo sildenafil citrate and in vitro 8-bromo-cGMP treatments on semen parameters and sperm function Fertil Steril.
- Sildenafil tablets LP 100 mg can cause visual disturbances in some users.
- Headaches are among the most common side effects reported.
- Avoid driving if you experience dizziness after taking the medication.
Effects of sildenafil (Viagra) administration on seminal parameters and post-ejaculatory refractory time in normal males Hum Reprod.
3. Liqrev
[13] Researchers found that a low sildenafil dose had no effect on sperm motility. also confirmed the positive effects of sildenafil on sperm motility in infertile patients. [11] Moreover, we reported no significant change in morphology, viscosity, and liquefaction time of semen after sildenafil administration compared with placebo. This is consistent with Purvis et al., who found that sildenafil had no significant effect on morphology, viscosity, and liquefaction time of semen after sildenafil administration. showed that sildenafil (100 mg) did not change sperm parameters of healthy patients and indicated that potential use of medication can be helpful in assisted reproductive techniques when ED temporarily occurs.
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reported that 125, 250, and 750 ng/mL sildenafil did not significantly change motility and viability of human sperm. also reported that the drug practically did not affect semen parameters and its volume and acidity. The findings of this study had some limitations. First, this was a single-center study; therefore, the results require further investigation. Second, the erectile and ejaculatory functions of participants were not measured.
Sildenafil Tablets or Oral Suspension for PAH
Third, sildenafil 50g the sample size of this study was small, and there was low power to detect an effect from sildenafil. Finally, patients only used one dose of sildenafil (50 mg) for evaluation. Hence, further studies seem to be required in this field. Selection bias limits the generalization of these findings because the type of participants in a city or a country could be different with other cities or countries and could be related to descent diversities. In Iran, sildenafil is the most prescribed medication to treat male sexual problems. Glenn DR, McVicar CM, McClure N, Lewis SE.
- Sildenafil tablets LP 100 mg is not an aphrodisiac; it enhances natural response.
- Sexual stimulation is necessary for the medication to work effectively.
- Discuss any underlying health conditions with your healthcare provider.
Sildenafil citrate improves sperm motility but causes a premature acrosome reaction in vitro Fertil Steril. Padma-Nathan H. Sildenafil citrate (Viagra) treatment for erectile dysfunction: An updated profile of response and effectiveness Int J Impot Res.
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Stirban A, Laude D, Elghozi JL, Sander D, Agelink MW, Hilz MJ, et al Acute effects of sildenafil on flow mediated dilatation and cardiovascular autonomic nerve function in type 2 diabetic patients Diabetes Metab Res Rev. Treatment of sexual dysfunctions secondary to male infertility with sildenafil citrate Fertil Steril.
| Ingredient | Quantity per Tablet | Function | Additional Notes |
|---|---|---|---|
| Sildenafil Citrate | 100 mg | Active ingredient | Main component for efficacy |
| Mannitol | 50 mg | Fillers, solubility enhancer | Helps tablet disintegration |
| Microcrystalline Cellulose | 20 mg | Binder | Provides structural support |
| Magnesium Stearate | 2 mg | Lubricant | Prevents tablet from sticking |
| Titanium Dioxide | 1 mg | Coloring agent | Opacity and white color |
Fisch JD, Behr B, Conti M.
| Step | Instruction | Notes |
|---|---|---|
| 1 | Take with a full glass of water | Can be taken with or without food |
| 2 | Administer approximately 30 minutes before planned activity | Peak effect within 1 hour |
| 3 | Do not exceed one tablet in 24 hours | Overdose may cause serious side effects |
| 4 | Consult doctor for use longer than 4 weeks or if ineffective | Possible adjustment of dose needed |
Enhancement of motility and acrosome reaction in human spermatozoa: Differential activation by type-specific phosphodiesterase inhibitors Hum Reprod. Type 5 phosphodiesterase regulation of human sperm motility Am J Obstet Gynecol. Use of the Sperm Quality Analyzer (SQA II-C) for the assessment of dog sperm quality Reprod Domest Anim. Patel AS, Leong JY, Ramasamy R. Prediction of male infertility by the World Health Organization laboratory manual for assessment of semen analysis: A systematic review Arab J Urol.
7.3 Amlodipine
The specimen was not placed in any purse, pocket, or briefcase. The semen samples were stored at 25°C in the laboratory. The semen parameters were measured by automated (SQA IIC-P, USA). [20] The condensation, viscosity, and appearance of specimens were evaluated by automated (SQA IIC-P, USA). Sperm concentration and count were calculated by automated (SQA IIC-P, USA).
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Sperm morphology was evaluated by eosin-hematoxylin staining. Sperm motility and kinetic were evaluated after 30 min at room temperature. Then, intervention and control groups were replaced after the washout period. Participants underwent a semen analysis approximately 1 week before receiving the first dose of sildenafil and placebo. Data of participants were extracted and then analyzed using SPSS statistical software version 16 IBM SPSS software, USA.
Missed Dose
Independent t-test and pairwise t-test were conducted. If the variables did not have normal distribution, nonparametric Mann–Whitney and Wilcoxon tests were used (P < 0.05). In the current study, 237 specimens from 79 participants were studied. The mean age of participants was 34 ± 5 years. The mean sperm counts in 79 patients were approximately 43.94 × 106 per ejaculation. In vitro effects of sildenafil and phentolamine, drugs used for erectile dysfunction, on human sperm motility Am J Obstet Gynecol. Claro JA, Ximenes SF, Nardozza A Jr., Andrade E, Messina L, Srougi M. Effect of sildenafil in cavernous arteries of patients with erectile dysfunction Int Braz J Urol.
- Sildenafil tablets LP 100 mg should be used with caution in renal impairment.
- Adjust dosage as recommended by your healthcare provider.
- Do not share your medication with others; it is for personal use only.
Harrold LR, Gurwitz JH, Field TS, Andrade SE, Fish LS, Jarry PD, et al The diffusion of a novel therapy into clinical practice: The case of sildenafil Arch Intern Med. The effects of sildenafil on human sperm function in healthy volunteers Br J Clin Pharmacol. The effect of sildenafil on human sperm motion and function from normal and infertile men Int J Impot Res.
5.5 Hearing Loss
To date, different studies have been reported that sildenafil could be useful to sperm function. The current study showed that sildenafil had no significant effect on semen parameters. Currently, PDE5 enzyme inhibitors, particularly sildenafil, are the first and most popular treatment options for men with impotence. However, the results of this study show that oral sildenafil citrate does not have any significant effect on any of the semen parameters. It is recommended that more studies should be conducted with a larger sample size, higher sildenafil doses (≥100 mg), and longer follow-up period.
Cite this article
We thank our colleagues from Urology Research Center, Guilan University of Medical Sciences, who provided insight and expertise that greatly assisted the study although they may not agree with all interpretations/conclusions of this paper. In the end, my coauthors and I decided to list Dr. Soheil Kianfar as a coauthor with a footnote stating that he passed away before publication. During the COVID-19 pandemic, Dr. Soheil Kianfar did his best to treat needy patients.
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He passed away in 2019 in this holy path before the publication of the manuscript. Porst H, Behre HM, Jungwirth A, Burkart M. Comparative trial of treatment satisfaction, efficacy and tolerability of sildenafil versus apomorphine in sildenafil citrate tables erectile dysfunction – An open, randomized cross-over study with flexible dosing Eur J Med Res. 5. du Plessis SS, de Jongh PS, Franken DR. Viagra is a brand name of sildenafil, approved by the FDA in the following formulation: Yes, the FDA has approved a generic version of Viagra. However, FDA approval doesn't guarantee the generic will be available in pharmacies. Note: Fraudulent online pharmacies may attempt to sell an illegal generic version of Viagra. These medications may be counterfeit and potentially unsafe.
- The medication may cause flushing and upset stomach in some users.
- Use with caution in elderly patients due to increased sensitivity.
- Monitor blood pressure regularly if prescribed for cardiovascular issues.
If you purchase medications online, be sure you are buying from a reputable and valid online pharmacy.
| Drug Class or Name | Effect on Sildenafil | Possible Outcome |
|---|---|---|
| Nitrates | Potentiate vasodilation | Risk of severe hypotension |
| Alpha-blockers | Enhanced blood pressure lowering | Caution advised, dose adjustments needed |
| CYP3A4 inhibitors (e.g., Ketoconazole) | Decrease sildenafil metabolism | Increased risk of side effects |
| Blood pressure medications | Additive effects | Monitor blood pressure closely |
Ask your health care provider for advice if you are unsure about the online purchase of any medication. The pricing data below reflects current availability in the marketplace and indicates that the medication is available for purchase.
7.1 Nitrates
Table 1 shows semen analysis in 79 participants at the baseline double-blind placebo-controlled, cross-over clinical trial on the administration of 50 mg sildenafil tablet Table 1. Conversely, Tables 2 and 3 show semen viscosity and liquefaction time analysis in Groups A sildenafil citrate 120 mg and B, including 39 and 40 participants, after double-blind placebo-controlled, cross-over clinical trial pre-post administration of 50 mg sildenafil and placebo tablets (P > 0.05) [Tables 2 and 3]. According to the results, 50 mg sildenafil did not have a sufficient effect on sperm motility and sperm viscosity at the baseline (P > 0.05). The comparison of semen quality and liquefaction time between sildenafil and placebo groups at phase II As shown in Table 4, 50 mg sildenafil and placebo tablets had no effects on ejaculatory fluid volume, semen viscosity, semen pH, sperm number, and sperm motility after sildenafil administration in both Groups (A and B) at Phase I (P > 0.05) [Table 4]. Moreover, no significant difference was shown between the volume of the ejaculatory fluid, semen viscosity, semen pH, number of sperms, baseline sperm motility, and sperm motility after administration in both Groups (A and B) at Phase II (P > 0.05) [Table 5].
Are you currently using Sildenafil (Viagra, Revatio)?
Effect of sildenafil and placebo on the changes of ejaculatory fluid volume, semen viscosity, semen pH, sperm count, sperm motility of patients at phase I Effect of sildenafil and placebo on the changes of ejaculatory fluid volume, semen viscosity, semen pH, sperm count, sperm motility of patients at phase II In this randomized, double-blind, controlled cross-over clinical trial, 79 participants were treated with 50 mg sildenafil and placebo. The mean age of patients was 34 ± 5 years, and the sperm number was 43.94 ± 64.06 (million) per ejaculation [Table 1]. This study demonstrated that 50 mg sildenafil tablet did not have any effect on semen viscosity and liquefaction time in Groups A and B (P > 0.05) [Tables 2 and 3]. The results show that 50 mg sildenafil tablet had no effects on ejaculatory fluid volume, semen viscosity, semen PH, sperm number, baseline sperm motility, and sperm motility after sildenafil administration in both Groups (A and B) at Phase I (P > 0.05) [Table 4]. We also found that there was no significant difference in ejaculatory fluid volume, semen viscosity, semen PH, sperm number, baseline sperm motility, and sperm motility after sildenafil administration in both Groups (A and B) at Phase II (P > 0.05) [Table 5].
Less common
showed that sildenafil has no effect on sperm count. [7,10,11] It was argued that PDE5 inhibitors increase secretory function. It is associated with increase in the serum insulin-like peptide concentrations in the sperm. [6] The studies showed that consumption of 100 mg sildenafil would increase sperm motility. [11,22,23,24] Studies showed that Type 4 and Type 5 inhibitors improve sperm motility.
